Somatic Mosaic Mutation Gradient Detected in Trace Brain Tissue From Stereo-EEG Depth Electrodes.

Zimeng Ye Mark F BennettAndrew NealJoshua A LaingMartin K HunnThanomporn WittayacharoenpongMarian TodaroSheila K PatelMelanie BahloPatrick KwanTerence J O'BrienIngrid Eileen Scheffer Samuel Frank Berkovic Piero PeruccaMichael S Hildebrand

Published in: Neurology (2022)

This study demonstrates proof-of-concept that mosaic gradients of pathogenic variants can be established using trace tissue from explanted SEEG electrodes.

Keyphrases

resting state
copy number
functional connectivity
heavy metals
reduced graphene oxide
white matter
working memory
optical coherence tomography
risk assessment
cerebral ischemia