Association of microRNA 17 host gene variant (rs4284505) with susceptibility and severity of systemic lupus erythematosus.

Abdelhady R Abdel-GawadSameerah Shaheen Nouf Abubakr Babteen Eman Ali Toraih Rami M Elshazli Manal S Fawzy Nawal S Gouda

Published in: Immunity, inflammation and disease (2020)

This study is the first one to explore that the MIR17HG rs4284505 is associated with SLE risk; (A/G) genotype conferred a protective effect, while the (G/G) genotype showed increased susceptibility to SLE and association with the disease severity in the study population.

Keyphrases

systemic lupus erythematosus
disease activity
cell proliferation
long non coding rna
genome wide
dna methylation
gene expression