Metabolic dysfunction and early-onset colorectal cancer - how macrophages build the bridge.
Katharina M ScheurlenAdrian T BilleterStephen J O'BrienSusan GalandiukPublished in: Cancer medicine (2020)
Tumor-promoting metabolites, such as itaconate, are directly regulating these mechanisms, thereby triggering carcinogenesis. Metabolic reprogramming in TAMs can build a bridge between metabolic dysfunction and the onset and progression of CRC through inflammatory pathways, particularly in younger patients with early-onset CRC.
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