Experimental evidence for proarrhythmic effects of nonsteroidal anti-inflammatory drugs in a sensitive whole-heart model.

Julian WolfesChristian EllermannSvenja BäumerMichael FehrKevin WillyFelix WegnerPatrick R LeitzLars EckardtGerrit Frommeyer

Published in: Basic & clinical pharmacology & toxicology (2021)

The perfusion with ibuprofen, indomethacin and diclofenac in commonly used doses raised the arrhythmia susceptibility in an established rabbit whole-heart model while APD shortening and shortened ERP seem to be crucial for arrhythmogenesis.

Keyphrases

anti inflammatory drugs
heart failure
atrial fibrillation
magnetic resonance imaging
magnetic resonance
computed tomography
postoperative pain