Impact of chemotherapy for breast cancer on leukocyte DNA methylation landscape and cognitive function: a prospective study.

Song YaoQiang HuSarah KernsLi YanAdedayo A OnitiloJamal MislehKelley YoungLianlian LeiJavier BautistaMostafa MohamedSupriya G MohileChristine B AmbrosoneSong LiuMichelle C Janelsins

Published in: Clinical epigenetics (2019)

Chemotherapy profoundly alters the composition and DNA methylation landscape of leukocytes in breast cancer patients. Our results shed light on the epigenetic response of circulating immune cell populations to cytotoxic chemotherapeutic drugs and provide possible epigenetic links to the degeneration of cognitive function associated with chemotherapy.

Keyphrases

dna methylation
gene expression
genome wide
locally advanced
peripheral blood
single cell
squamous cell carcinoma
copy number