Comparison of renal histopathology and gene expression profiles between severe COVID-19 and bacterial sepsis in critically ill patients.
Meint VolbedaDaniela Jou-ValenciaMarius C van den HeuvelMarjolein KnoesterPeter J ZwiersJanesh PillayStefan P BergerPeter H J van der VoortJan G ZijlstraMatijs van MeursJill MoserPublished in: Critical care (London, England) (2021)
In a small cohort of postmortem kidney biopsies from COVID-19 patients, we observed distinct histopathological and gene expression profiles between COVID-19-AKI and bacterial sepsis-AKI. COVID-19 was associated with more severe ATN and microvascular thrombosis coupled with decreased microvascular flow, yet minimal inflammation. Further studies are required to determine whether these observations are a result of true pathophysiological differences or related to the timing of biopsy after disease onset.