A GSH-activatable ruthenium(ii)-azo photosensitizer for two-photon photodynamic therapy.

Leli ZengShi KuangGuanying LiChengzhi JinLiangnian JiHui Chao

Published in: Chemical communications (Cambridge, England) (2018)

A glutathione (GSH)-activatable ruthenium(ii)-azo photosensitizer was prepared. The complex had low toxicity towards cells under dark conditions. It exhibited excellent phototoxicity under two-photon excitation (810 nm) and thus was developed as a two-photon photodynamic anticancer agent for cancer therapy.

Keyphrases

photodynamic therapy
fluorescent probe
living cells
fluorescence imaging
cancer therapy
induced apoptosis
drug delivery
cell cycle arrest
oxidative stress
monte carlo
signaling pathway
endoplasmic reticulum stress
cell death
cell proliferation
energy transfer