Comparison of pharmacokinetics, safety and tolerability of secukinumab administered subcutaneously using different delivery systems in healthy volunteers and in psoriasis patients.
Gerard BruinHans-Ulrich P HockeyPhillip La StellaBárdur SigurgeirssonRong FuManmath PatekarPascal CharefRalph WoessnerBruno Boutouyrie-DumontPublished in: British journal of clinical pharmacology (2020)
Collective evidence from both studies demonstrated that 2-mL injections of secukinumab into the abdomen or thigh using different devices resulted in comparable PK characteristics and were all well tolerated without noticeable local reactions.