Interaction of HSD11B1 and H6PD polymorphisms in subjects with type 2 diabetes are protective factors against obesity: a cross-sectional study.

Marcio F ChedidFilipe V do NascimentoFernanda S de OliveiraBianca M de SouzaCleber R P KruelRichard R GurskiLuis H CananiDaisy CrispimFernando Gerchman

Published in: Diabetology & metabolic syndrome (2019)

These polymorphisms might interact in the protection against obesity in T2DM individuals. Obese individuals may have decreased intra-abdominal VAT HSD11B1 gene expression resulting in decreasing intra-abdominal cortisol levels as a compensatory mechanism against central and general adiposity.

Keyphrases

insulin resistance
weight loss
metabolic syndrome
gene expression
weight gain
type diabetes
adipose tissue
high fat diet induced
bariatric surgery
dna methylation
skeletal muscle
physical activity
glycemic control
risk factors