Dual IGF1R/IR inhibitors in combination with GD2-CAR T-cells display a potent anti-tumor activity in diffuse midline glioma H3K27M-mutant.

Emmanuel de BillyMarsha PellegrinoDomenico OrlandoGiulia PericoliRoberta FerrettiPietro BusinaroMaria Antonietta Ajmone-CatSabrina RossiLucia Lisa PetrilliNicola MaestroFrancesca Diomedi-CamasseiMarco PezzulloCristiano De StefanisPaola BencivengaAlessia PalmaRossella RotaFrancesca Del BufaloLuca MassimiGerrit WeberChris JonesAndrea CaraiSimona CarusoBiagio De AngelisIgnazio CaruanaConcetta QuintarelliAngela Mastronuzzi Franco Locatelli Maria Vinci

Published in: Neuro-oncology (2022)

Our study supports the development of IGF1R/IR inhibitors to be used in combination with GD2-CAR T-cells for treating patients affected by DMG/DIPG and, potentially, by pHGG.

Keyphrases

end stage renal disease
induced apoptosis
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
prognostic factors
cell cycle arrest
binding protein
cell death
patient reported outcomes
oxidative stress
cell proliferation
endoplasmic reticulum stress
anti inflammatory
patient reported