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SKP alleviates the ferroptosis in diabetic kidney disease through suppression of HIF-1α/HO-1 pathway based on network pharmacology analysis and experimental validation.

Yangtian YanNingning YuanYuchi ChenYun MaAli ChenFujing WangShihua YanZhuo'en HeJinyue HeChi ZhangHao WangMingqing WangJianxin DiaoWei Xiao
Published in: Chinese medicine (2024)
SKP potentially mitigating renal injury in DKD by subduing ferroptosis through the intricacies of the HIF-1α/HO-1 signaling pathway.
Keyphrases
  • pi k akt
  • signaling pathway
  • cell death
  • endothelial cells
  • type diabetes
  • epithelial mesenchymal transition
  • mouse model
  • wound healing
  • oxidative stress