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Risk factors for recognized and unrecognized SARS-CoV-2 infection: a seroepidemiologic analysis of the Prospective Urban Rural Epidemiology (PURE) study.

Darryl P LeongMark LoebPrem K MonySumathy RangarajanMaha MushtahaMatthew S MillerMary DiasSergey YegorovMamatha VOzge Telci CakliliAhmet TemizhanAndrzej SzubaMarc Evans M AbatNafiza Mat-NasirMaria Luz DiazHamda KhansahebPatricio Lopez-JaramilloMyLinh DuongKoon K TeoPaul PoirierGustavo OliveiraÁlvaro AvezumSalim Yusuf
Published in: Microbiology spectrum (2024)
In this large, international study, evidence of SARS-CoV-2 infection was obtained by testing blood specimens from 8,719 community-dwelling adults from 11 countries. The key findings are that (i) the large majority (83%) of community-dwelling adults from several high-, middle-, and low-income countries with blood test evidence of SARS-CoV-2 infection were unaware of this infection-especially in lower-income countries; and (ii) overweight/obesity predisposes to SARS-CoV-2 infection, while COVID-19 vaccination is associated with a reduced risk of SARS-CoV-2 infection. These observations are not attributable to other individual characteristics, highlighting the importance of the COVID-19 vaccination to prevent not only severe infection but possibly any infection. Further research is needed to understand the mechanisms by which overweight/obesity might increase the risk of SARS-CoV-2 infection.
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