Intranasal Administration of Brain-Derived Neurotrophic Factor Rescues Depressive-Like Phenotypes in Chronic Unpredictable Mild Stress Mice.

Xiao-Ling LiHua LiuShu-Han LiuYong Cheng Guo-Jun Xie

Published in: Neuropsychiatric disease and treatment (2022)

Taken together, our results for the first time demonstrated that intranasal delivery of BDNF protein exhibited anti-depressant-like effects in mice, and therefore may represent a new therapeutic strategy for major depressive disorder.

Keyphrases

major depressive disorder
bipolar disorder
stress induced
high fat diet induced
mouse model
type diabetes
wild type
skeletal muscle
binding protein
drug induced