Biomarkers of oxidative stress and its nexus with haemoglobin variants and adverse foeto-maternal outcome among women with preeclampsia in a Ghanaian population: A multi-centre prospective study.

Ganiwu AbdulWilliam Osei-WusuGordon Akuffo AsareSamira DaudStephen OpokuValentine Christian Kodzo Tsatsu Tamakloe Joseph Frimpong Benedict SackeyWina Ivy Ofori BoaduVivian PaintsilMax Efui Annani-AkollorYaw Amo WiafeEnoch Odame AntoOtchere Addai-Mensah

Published in: PloS one (2023)

Reduced levels of vitamin C are common among preeclamptics with at least one copy of the HbC variant. Haemoglobin variants in preeclampsia contribute to adverse foeto-maternal outcomes with Haemoglobin S variants being the most influencing factor for PPH, HELLP, preterm labour, NICU admission, and neonatal jaundice.

Keyphrases

pregnancy outcomes
copy number
oxidative stress
early onset
birth weight
emergency department
preterm infants
gestational age
pregnant women
dna damage
gene expression
insulin resistance
metabolic syndrome
adipose tissue
weight loss
ischemia reperfusion injury
skeletal muscle
heat stress
dna methylation