Simultaneous Broadband Suppression of Homonuclear and Heteronuclear Couplings in 1 H NMR Spectroscopy.
Coral MycroftMathias NilssonGareth A MorrisLaura CastañarPublished in: Chemphyschem : a European journal of chemical physics and physical chemistry (2022)
The 1 H NMR analysis of species containing NMR-active heteronuclei can be difficult due to signal overlap caused by the combined effects of homonuclear and heteronuclear scalar (J) couplings. Here, a general pure shift method is presented for obtaining ultra-high resolution 1 H NMR spectra where spectral overlap is drastically reduced by suppressing both homonuclear and heteronuclear J-couplings, giving one single signal per 1 H chemical environment. Its usefulness is demonstrated in the analysis of fluorine- and phosphorus-containing compounds of pharmaceutical and biochemical interest.
Keyphrases
- high resolution
- magnetic resonance
- solid state
- high speed
- mass spectrometry
- optical coherence tomography
- tandem mass spectrometry
- positron emission tomography
- computed tomography
- pet imaging
- density functional theory
- magnetic resonance imaging
- sewage sludge
- heavy metals
- molecular dynamics
- risk assessment
- genetic diversity
- dual energy