AGR2-mediated unconventional secretion of 14-3-3ε and α-actinin-4, responsive to ER stress and autophagy, drives chemotaxis in canine mammary tumor cells.

Stephen Hsien-Chi YuanChih-Ching WuYu-Chih WangXiu-Ya ChanHao-Wei ChuYoungsen YangHao-Ping Liu

Published in: Cellular & molecular biology letters (2024)

This study elucidates AGR2's pivotal role in orchestrating unconventional secretion of 14-3-3ε and α-actinin 4 from CMT cells, thereby contributing to paracrine-mediated chemotaxis. The insight into the intricate interplay between AGR2-involved ER stress, autophagy, and unconventional secretion provides a foundation for refining strategies aimed at impeding metastasis in both canine mammary tumors and potentially human cancers.

Keyphrases

induced apoptosis
endoplasmic reticulum stress
cell death
signaling pathway
cell cycle arrest
oxidative stress
endothelial cells
young adults
cell proliferation
childhood cancer