Role of IL-6 and STAT3 signaling in dihydropyridine-induced gingival overgrowth fibroblasts.

Sao-Lun LuChiung-Fang HuangChuan-Li LiHsein-Kun LuSam Li-Sheng Chen

Published in: Oral diseases (2020)

Gingival inflammation (e.g., IL-1β) and taking dihydropyridine (e.g., Nif) may additively stimulate Col overproduction through the IL-6-STAT3-Colα1(I) cascade in DIGO cells. IL-6-STAT3 signaling may be considered a target for the control of DIGO.

Keyphrases

cell proliferation
oxidative stress
induced apoptosis
high glucose
cell cycle arrest
diabetic rats
signaling pathway
drug induced
stress induced