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Role of IL-6 and STAT3 signaling in dihydropyridine-induced gingival overgrowth fibroblasts.

Sao-Lun LuChiung-Fang HuangChuan-Li LiHsein-Kun LuSam Li-Sheng Chen
Published in: Oral diseases (2020)
Gingival inflammation (e.g., IL-1β) and taking dihydropyridine (e.g., Nif) may additively stimulate Col overproduction through the IL-6-STAT3-Colα1(I) cascade in DIGO cells. IL-6-STAT3 signaling may be considered a target for the control of DIGO.
Keyphrases
  • cell proliferation
  • oxidative stress
  • induced apoptosis
  • high glucose
  • cell cycle arrest
  • diabetic rats
  • signaling pathway
  • drug induced
  • stress induced