Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception.

Roderick C SliekerCaroline L ReltonTom R GauntP Eline SlagboomBastiaan T Heijmans

Published in: Epigenetics & chromatin (2018)

Our analysis shows that age-related DNA methylation changes are highly tissue-specific. These results may guide the development of improved tissue-specific markers of chronological and, perhaps, biological age.

Keyphrases

dna methylation
genome wide
gene expression
copy number
transcription factor