Wnt/β-catenin-mediated signaling re-activates proliferation of matured cardiomyocytes.

Yong FanBeatrice Xuan HoJeremy Kah Sheng PangNicole Min Qian PekJin Hui HorShi-Yan NgBoon-Seng Soh

Published in: Stem cell research & therapy (2018)

Although both N-cadherin antibody and CHIR99021 treatment resulted in increased Wnt signaling and cardioproliferation, CHIR99021 was found to be the more effective treatment method for human ES cell-derived cardiomyocytes. Therefore, we propose that CHIR99021 could be a potential therapeutic option for myocardial infarction patients in need of regeneration of cardiac tissue.

Keyphrases

stem cells
end stage renal disease
cell proliferation
endothelial cells
left ventricular
heart failure
ejection fraction
chronic kidney disease
signaling pathway
peritoneal dialysis
combination therapy
patient reported outcomes
wound healing