Distinct immune signature predicts progression of vestibular schwannoma and unveils a possible viral etiology.
Moran AmitTongxin XieFrederico O Gleber-NettoPatrick J HuntGautam U MehtaDiana BellDeborah A SilvermanIsmail YamanYi YeJared K BurksGregory N FullerPaul W GidleyMarc-Elie NaderShaan M RazaFranco DeMontePublished in: Journal of experimental & clinical cancer research : CR (2022)
Rapid progression of residual vestibular schwannoma following subtotal surgical resection has an underlying immune etiology that may be virally originating; and despite an abundant adaptive immune response, T-cell immunosenescence may be associated with rapid progression of VS. These findings provide a rationale for clinical trials evaluating immunotherapy in patients with rapidly progressing VS.