Mesothelin Secretion by Pancreatic Cancer Cells Co-opts Macrophages and Promotes Metastasis.

Teifion Luckett Maidinaimu Abudula Lucy Ireland Mark Glenn Gaia Bellomo Ruth Stafferton Christopher M Halloran Paula Ghaneh Robert P Jones Michael C Schmid Ainhoa Mielgo

Published in: Cancer research (2024)

Mesothelin secretion by cancer cells supports pancreatic cancer metastasis by inducing macrophage secretion of VEGFA and S100A9 to support cancer cell proliferation and survival, recruit neutrophils, and stimulate neutrophil extracellular trap formation. See related commentary by Alewine, p. 513.

Keyphrases

cell proliferation
papillary thyroid
adipose tissue
squamous cell
pi k akt
free survival