Layer-by-layer construction of an oxygen-generating photo-responsive nanomedicine for enhanced photothermal and photodynamic combination therapy.

Published in: Chemical communications (Cambridge, England) (2019)

A multifunctional photosensitive and photothermal nanomedicine, AMP-Ce6-HA, was prepared by sequentially layering hard and soft functional molecules. AMP-Ce6-HA was efficiently picked up by MDA-MB-231 breast cancer cells, and then released oxygen in lysosomes. The photothermal and oxygen-enhanced photodynamic combination therapy was much more effective than the single one.

Keyphrases

cancer therapy
combination therapy
breast cancer cells
drug delivery
protein kinase
energy transfer
cell death