Efficacy and safety of colistin plus beta-lactams for bone and joint infection caused by fluoroquinolone-resistant gram-negative bacilli: a prospective multicenter study.

Mikel Mancheño-LosaOscar MurilloEva BenaventLuisa SorlíMelchor RieraJavier CoboNatividad BenitoLaura MorataAlba RiberaBeatriz SobrinoMarta Fernández-SampedroElena MúñezAlberto BahamondeJosé María BarberoMaria Dolores Del ToroJenifer VillaRaül Rigo-BonninSonia LuqueIsabel García-LuqueAntonio OliverJaime EstebanJaime Lora-Tamayo

Published in: Infection (2024)

Combination therapy with intravenous beta-lactams plus colistin is an effective regimen for BJI caused by fluoroquinolone-resistant GNB. AEs were reversible and potentially preventable by close therapeutic drug monitoring.

Keyphrases

gram negative
combination therapy
multidrug resistant
acinetobacter baumannii
drug resistant
klebsiella pneumoniae
high dose
escherichia coli
emergency department
pseudomonas aeruginosa
bone loss
low dose
drug induced