Obesity, diabetes and risk of bone fragility: How BMAT behavior is affected by metabolic disturbances and its influence on bone health.
Gregório Corrêa GuimarãesJoão Bosco Costa CoelhoJoão Gabriel Oliveira SilvaAna Carolina Chalfun de Sant'AnaCássia Alves Carrilho de SáJúlia Marques MorenoLívia Marçal ReisCamila Souza de Oliveira GuimaraesPublished in: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2023)
By secreting a broad range of factors, BMAT modulates the bone microenvironment and metabolism, ultimately affecting skeletal health. A better understanding of the relationship between BMAT expansion and metabolic disturbances observed in diabetic and obese patients will help to identify regulatory pathways and new targets for the treatment of bone-related diseases, with BMAT as a potential therapeutic target.
Keyphrases
- bone mineral density
- obese patients
- type diabetes
- healthcare
- public health
- bone loss
- soft tissue
- bariatric surgery
- bone regeneration
- mental health
- metabolic syndrome
- cardiovascular disease
- insulin resistance
- postmenopausal women
- adipose tissue
- gastric bypass
- roux en y gastric bypass
- body composition
- physical activity
- climate change
- body mass index
- combination therapy
- high fat diet induced
- hip fracture