Fusobacterium nucleatum Extracellular Vesicles Promote Experimental Colitis by Modulating Autophagy via the miR-574-5p/CARD3 Axis.

Shuchun WeiJixiang ZhangXiaohan WuMeilin ChenHancheng HuangSuqi ZengZixuan XiangXiangyun LiWeiguo Dong

Published in: Inflammatory bowel diseases (2022)

Here, we describe a new mechanism by which Fn-EVs mediate experimental colitis severity through miR-574-5p/CARD3-dependent autophagy activation, providing a novel target for UC monitoring and targeted therapy.

Keyphrases

signaling pathway
cell death
endoplasmic reticulum stress
oxidative stress
ulcerative colitis