Performance of the 2017 EULAR/ACR classification criteria for inflammatory myopathies in patients with myositis-specific autoantibodies.

Maria Casal-DominguezIago Pinal-FernandezKatherine PakWilson HuangAlbert Selva-O'CallaghanJemima Albayda Livia A Casciola-Rosen Julie J Paik Eleni Tiniakou Christopher A MecoliThomas E LloydSonye K DanoffLisa Christopher-Stine Andrew Lee Mammen

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2021)

Although the EULAR/ACR criteria successfully classified 91% of MSA-positive myositis patients, certain MSA-defined subgroups, including those with autoantibodies against HMGCR, SRP, and PL7, are frequently misclassified. In myositis patients with MSAs, autoantibodies outperform the EULAR/ACR-defined subgroups to predict clinical phenotypes. These findings underscore the need to include MSAs in a revised myositis classification scheme.

Keyphrases

interstitial lung disease
systemic lupus erythematosus
myasthenia gravis
machine learning
end stage renal disease
deep learning
systemic sclerosis
ejection fraction
chronic kidney disease
oxidative stress
rheumatoid arthritis
idiopathic pulmonary fibrosis
patient reported outcomes
patient reported