Unravelling the potential of TIM-3 gene polymorphism in allogeneic hematopoietic stem cell transplantation - a preliminary study.
Sylwia BiałyJagoda SiemaszkoMałgorzata Sobczyk-KruszelnickaWojciech FidykIwona SolarskaBarbara Nasiłowska-AdamskaPatrycja SkowrońskaMaria BieniaszewskaAgnieszka TomaszewskaGrzegorz W BasakSebastian GiebelTomasz WróbelKatarzyna Bogunia-KubikPublished in: Transplant immunology (2024)
Polymorphism of TIM-3 molecule may affect the immune response in HSCT patients. The recessive alleles of rs1036199 and rs10515746 SNPs decreased the risk of developing aGvHD. TIM-3 donor-recipient genetic matching may also affect the risk of post-transplant CMV infection, indicating the potential value of genetic profiling in optimizing transplant strategies.
Keyphrases
- allogeneic hematopoietic stem cell transplantation
- immune response
- genome wide
- end stage renal disease
- newly diagnosed
- acute lymphoblastic leukemia
- ejection fraction
- acute myeloid leukemia
- chronic kidney disease
- prognostic factors
- copy number
- patient reported outcomes
- dendritic cells
- risk assessment
- inflammatory response
- muscular dystrophy