TGF-β1 induces amoeboid-to-mesenchymal transition of CD44high oral squamous cell carcinoma cells via miR-422a downregulation through ERK activation and Cofilin-1 phosphorylation.
Sho YokoyamaHideo ShigeishiHiroshi MurodumiMiyuki SakumaHiroki KatoKoichiro HigashikawaKouji OhtaMasaru SugiyamaMasaaki TakechiPublished in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2020)
Cofilin-1 is involved in the invasive ability of CD44high OSCC cells. TGF-β1 contributes to AMT by downregulation of miR-422a via ERK activation and Cofilin-1 phosphorylation. Our findings suggest that miR-422a and Cofilin-1 play major roles in the maintenance of amoeboid-like CD44high cells.