Multiparametric chemical exchange saturation transfer MRI detects metabolic changes in breast cancer following immunotherapy.
Emily HoffmannDaniel SchacheCarsten HöltkeJens SoltwischStephan NilandTobias KrählingKlaus BerganderMartin GrewerChristiane GeyerLinda GroenewegJohannes A EbleThomas VoglJohannes RothWalter HeindelBastian MausAnne HelfenCornelius FaberMoritz WildgruberMirjam GerwingVerena HoerrPublished in: Journal of translational medicine (2023)
Multiparametric CEST-MRI enables non-invasive assessment of metabolic signatures of the TME, allowing both for estimation of the degree of tumor malignancy and for assessment of early response to immune checkpoint inhibition.