2-[Carbamo-thio-yl(2-hy-droxy-eth-yl)amino]-ethyl benzoate: crystal structure, Hirshfeld surface analysis and computational study.
Sang Loon TanEdward R T TiekinkPublished in: Acta crystallographica. Section E, Crystallographic communications (2020)
The title di-substituted thio-urea, C12H16N2O3S, has the hy-droxy-lethyl and ethyl benzoate substituents bound to the same amine-N atom, and is twisted, having a (+)syn-clinal conformation with the Namine-C-C-O(hydroxyl, carbon-yl) torsion angles of 49.39 (13) and 59.09 (12)°, respectively; the dihedral angle between the almost planar CN2S core and the pendent benzene ring is 69.26 (4)°. In the crystal, supra-molecular layers propagating in the ac plane are formed via a combination of hydroxyl-O-H⋯S(thione), amine-N-H⋯O(hydroxyl, carbon-yl) hydrogen-bonds. The layers stack along the b axis with inter-digitation of the benzene rings allowing the formation of π-π stacking [inter-centroid separation = 3.8722 (7) Å] and parallel C=O⋯π inter-actions. A computational chemistry study shows the conventional hydrogen bonding in the crystal leads to significant electrostatic stabilization but dispersion terms are also apparent, notably through the inter-actions involving the benzene residue.
Keyphrases
- crystal structure
- ionic liquid
- high resolution
- molecular dynamics simulations
- molecular dynamics
- lymph node metastasis
- computed tomography
- magnetic resonance imaging
- staphylococcus aureus
- escherichia coli
- magnetic resonance
- molecular docking
- solar cells
- cystic fibrosis
- amino acid
- drug discovery
- diffusion weighted imaging