Role of serotonin and norepinephrine transporters in antidepressant-induced arterial hypertension: a pharmacoepidemiological-pharmacodynamic study.

Jean-Louis MontastrucVanessa RousseauClaire de CanecaudeAnne RoussinFrançois Montastruc

Published in: European journal of clinical pharmacology (2020)

The present study found a positive association between the NET/SERT pKi ratio and the occurrence of arterial hypertension with SRI and SNRI antidepressants. These results are important for the selection of antidepressants in hypertensive and/or at risk depressive patients as well as for future development of antidepressants devoid of hypertensive effect.

Keyphrases

arterial hypertension
major depressive disorder
blood pressure
end stage renal disease
newly diagnosed
bipolar disorder
prognostic factors
oxidative stress
stress induced