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In situ vaccination at a peripheral tumor site augments response against melanoma brain metastases.

Paul A ClarkRaghava N SriramaneniWon Jong JinJustin C JagodinskyAmber M BatesAbigail A JaquishBryce R AndersonTrang LeJonathan A LubinIshan ChakravartyIan S ArthurClinton M HeinzeEmily I GuyJasdeep KlerKelsey A KlarPeter M CarlsonKyung Mann KimJohn S KuoZachary S Morris
Published in: Journal for immunotherapy of cancer (2021)
ISV augmented response to ICIs in murine melanoma at brain and extracranial tumor sites. Although baseline tumor-immune microenvironments were similar at brain and extracranial tumor sites, response to ISV+α-CTLA-4 was divergent with reduced infiltration and activation of immune cells in brain tumors. Additional therapies may be needed for effective antitumor immune response against melanoma brain metastases.
Keyphrases
  • brain metastases
  • small cell lung cancer
  • immune response
  • internal carotid artery
  • skin cancer
  • inflammatory response
  • toll like receptor