In situ vaccination at a peripheral tumor site augments response against melanoma brain metastases.
Paul A ClarkRaghava N SriramaneniWon Jong JinJustin C JagodinskyAmber M BatesAbigail A JaquishBryce R AndersonTrang LeJonathan A LubinIshan ChakravartyIan S ArthurClinton M HeinzeEmily I GuyJasdeep KlerKelsey A KlarPeter M CarlsonKyung Mann KimJohn S KuoZachary S MorrisPublished in: Journal for immunotherapy of cancer (2021)
ISV augmented response to ICIs in murine melanoma at brain and extracranial tumor sites. Although baseline tumor-immune microenvironments were similar at brain and extracranial tumor sites, response to ISV+α-CTLA-4 was divergent with reduced infiltration and activation of immune cells in brain tumors. Additional therapies may be needed for effective antitumor immune response against melanoma brain metastases.