Advanced Atrioventricular Block in Athletes: Prevalence and Role of Anti-Ro/Sjögren Syndrome-Related Antigen A Antibodies.
Pietro Enea LazzeriniIacopo BertolozziAlessandra CartocciVamsi Krishna Murthy GinjupalliPietro Alberto TeneggiDavide PicaGiovanni MericoIrene BogazziViola SalviniRiccardo AccioliFabio SalvadoriTommaso MarzottiGabriele CeveniniMatteo CapecchiSilvia CantaraAnna CantoreMaria InfantinoStefania BisognoFrancesco FinizolaFlavio D'ascenziFranco Laghi-PasiniMaurizio AcampaPier Leopoldo CapecchiMohamed BoutjdirPublished in: Journal of the American Heart Association (2024)
Our study provides evidence that advanced AVB occurs in young athletes, in most cases associated with anti-Ro/SSA antibodies blocking L-type calcium channels. These findings may open new avenues for immunomodulating therapies to reduce the risk of life-threatening events in athletes, avoiding or delaying pacemaker implantation.