Molecular signature of response to preoperative radiotherapy in locally advanced breast cancer.

Miljana TanićAna KrivokućaMilena ČavićJasmina MladenovićVesna Plesinac KarapandžićStephan BeckSiniša RadulovićSnezana SusnjarRadmila Janković

Published in: Radiation oncology (London, England) (2018)

This study pinpoints MAP3K4 as a putative biomarker of response to RT in both preoperative and postoperative settings and a potential target for radiosensitising combination therapy, warranting further pre-clinical studies and prospective clinical validation.

Keyphrases

combination therapy
locally advanced
patients undergoing
rectal cancer
squamous cell carcinoma
neoadjuvant chemotherapy
radiation therapy
early stage
phase ii study
radiation induced
risk assessment
young adults
single molecule
study protocol
childhood cancer
open label
double blind