Whole-Genome Sequencing Analysis Reveals New Susceptibility Loci and Structural Variants Associated with Progressive Supranuclear Palsy.
Hui WangTimothy S ChangBeth A DombroskiPo-Liang ChengVishakha PatilLeopoldo Valiente-BanuetKurt FarrellCatriona McleanLaura Molina-PorcelAlex RajputPeter Paul de DeynNathalie Le BastardMarla GearingLaura Donker KaatJohn C Van SwietenElise DopperBernardino F GhettiKathy L NewellClaire TroakesJusto G de YébenesAlberto Rábano-GutierrezTina MellerWolfgang Hermann OertelGesine RespondekMaria StamelouThomas ArzbergerSigrun RoeberUlrich MüllerFranziska HopfnerPau PastorAlexis BriceAlexandra DürrIsabelle Le BerThomas G BeachGeidy E SerranoLili-Naz HazratiIrene LitvanRosa RademakersOwen A RossDouglas GalaskoAdam L BoxerBruce L MillerWillian W SeeleyVivanna M Van DeerlinEdward B LeeCharles L WhiteHuw R MorrisRohan de SilvaJohn F CraryAlison Mary GoateJeffrey S FriedmanYuk Yee LeungGiovanni CoppolaAdam C NajLi-San Wangnull nullGourisankar GhoshGünter U HöglingerGerard D SchellenbergDaniel H GeschwindWan-Ping LeePublished in: medRxiv : the preprint server for health sciences (2024)
Through WGS, we significantly enhanced our understanding of the genetic basis of PSP, providing new targets for exploring disease mechanisms and therapeutic interventions.