In silico screening for ERα down modulators identifies thioridazine as an anti-proliferative agent in primary, 4OH-tamoxifen-resistant and Y537S ERα-expressing breast cancer cells.
Claudia BusoneroStefano LeoneFabrizio BianchiFilippo AcconciaPublished in: Cellular oncology (Dordrecht) (2018)
We suggest that modulation of the intracellular ERα concentration in BC cells can be exploited in in silico screens to identify anti-BC drugs and uncover a re-purposing opportunity for thioridazine in the treatment of primary and metastatic ET resistant BCs.
Keyphrases
- breast cancer cells
- estrogen receptor
- molecular docking
- genome wide
- induced apoptosis
- endoplasmic reticulum
- squamous cell carcinoma
- small molecule
- small cell lung cancer
- cell cycle arrest
- high throughput
- dna methylation
- reactive oxygen species
- signaling pathway
- endoplasmic reticulum stress
- oxidative stress
- cell proliferation
- cell death
- single cell