A New Intraepithelial γδ T-Lymphocyte Marker for Celiac Disease Classification in Formalin-Fixed Paraffin-Embedded (FFPE) Duodenal Biopsies.

Alina PoppJuha TaavelaPaolo GrazianoPaola ParenteClaudia CovelliCarmela LamacchiaAngelo AndriulliMarkku MäkiJorma Isola

Published in: Digestive diseases and sciences (2020)

Intraepithelial γδ T-lymphocytes can be stained and quantitated reliably in FFPE duodenal biopsies. The results showed excellent specificity and sensitivity for celiac disease. The new IHC method of detection of γδ-IELs is a promising addition to the routine histopathologic assessment methodology of celiac disease.

Keyphrases

celiac disease
high grade
machine learning
deep learning
ultrasound guided
clinical practice
peripheral blood
loop mediated isothermal amplification
label free