SOX17 Deficiency Mediates Pulmonary Hypertension: At the Crossroads of Sex, Metabolism, and Genetics.
Shreya SangamXutong SunTae-Hwi Schwantes-AnManivannan YegambaramQing LuYinan ShiTodd CookAmanda FisherAndrea L FrumpAnna ColemanYanan SunShuxin LiangHoward CrawfordKatie A LutzAvinash D MaunMichael W PauciuloJason H KarnesKetul R ChaudharyDuncan J StewartPaul R LanglaisMohit JainMona AlotaibiTim LahmYan JinHaiwei GuHaiyang TangWilliam C NicholsStephen M BlackAnkit A DesaiPublished in: American journal of respiratory and critical care medicine (2023)
Cumulatively, SOX17 promotes mitochondrial bioenergetics and attenuates PAH, in part, via inhibition of HIF-2α. 16αOHE mediates PAH development via downregulation of SOX17, linking sexual dimorphism and SOX17 genetics in PAH. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).