pSTM6-275, a Conjugative IncHI2 Plasmid of Salmonella enterica That Confers Antibiotic and Heavy-Metal Resistance under Changing Physiological Conditions.
Helen Billman-JacobeYuhong LiuRuth HaitesTom WeaverLily RobinsonMarc MarendaMichael Dyall-SmithPublished in: Antimicrobial agents and chemotherapy (2018)
Detailed annotation of an IncHI2 plasmid, pSTM6-275, from Salmonella enterica serotype 1,4,5,12:i:- strain TW-Stm6 revealed a composite structure, including antimicrobial resistance genes on mobile genetic elements. The plasmid was thermosensitive for transfer to Escherichia coli and conferred reduced susceptibility to antibiotics, copper sulfate, and silver nitrate. Metal ion susceptibility was dependent on physiological conditions, giving an insight into the environments where this trait might confer a fitness advantage.
Keyphrases
- escherichia coli
- antimicrobial resistance
- genome wide
- heavy metals
- klebsiella pneumoniae
- crispr cas
- biofilm formation
- gold nanoparticles
- nitric oxide
- physical activity
- body composition
- dengue virus
- copy number
- single cell
- dna methylation
- risk assessment
- health risk
- multidrug resistant
- gene expression
- cystic fibrosis
- zika virus
- antibiotic resistance genes
- candida albicans
- bioinformatics analysis
- anaerobic digestion