Impaired human immunodeficiency virus type 1 replicative fitness in atypical viremic non-progressor individuals.
Jan WeberRichard M GibsonLenka SáckáDmytro StruninJan HodekJitka WeberováMarcela PávováDavid J AlouaniRobert AsaadBenigno RodriguezMichael M LedermanMiguel E Quiñones-MateuPublished in: AIDS research and therapy (2017)
It is likely that complex multifactorial parameters govern HIV-1 disease progression in each individual, starting with the infecting virus (phenotype, load, and quasispecies diversity) and the intrinsic ability of the host to respond to the infection. Here we analyzed a subset of viremic controller patients and demonstrated that similar to the phenomenon observed in patients with a discordant response to antiretroviral therapy (i.e., high CD4+ cell counts with detectable plasma HIV-1 RNA load), reduced viral replicative fitness seems to be linked to slow disease progression in these antiretroviral-naïve individuals.
Keyphrases
- human immunodeficiency virus
- antiretroviral therapy
- hiv infected
- hiv positive
- hiv aids
- hiv infected patients
- hepatitis c virus
- end stage renal disease
- physical activity
- newly diagnosed
- body composition
- chronic kidney disease
- ejection fraction
- sars cov
- peritoneal dialysis
- men who have sex with men
- prognostic factors
- hiv testing
- single cell