DNA Methyltransferase 3B-Mediated Intratumoral Heterogeneity and Therapeutic Targeting in Breast Cancer Recurrence and Metastasis.

Jae Young So Howard Hua Yang Woo Yong Park Nicolas Skrypek Hiroki Ishii Jennifer M Chen Maxwell Ping Lee Li Yang

Published in: Molecular cancer research : MCR (2022)

Our findings of transcriptome changes mediated by DNMT3B provide new mechanistic insight for intratumor heterogeneity and chemoresistance, and therapeutic targeting of DNMT3B in combination with chemotherapy offer additional treatment options for metastatic disease especially for patients with TNBC.

Keyphrases

single cell
dna methylation
cancer therapy
rna seq
squamous cell carcinoma
small cell lung cancer
genome wide
gene expression
circulating tumor
locally advanced
cell free
single molecule
drug delivery
radiation therapy
young adults
rectal cancer