Simvastatin enhances radiation sensitivity of colorectal cancer cells.
Georgios KaragkounisJennifer DeVecchioSylvain FerrandonMatthew F KaladyPublished in: Surgical endoscopy (2017)
Treatment with simvastatin hindered CRC cell viability and enhanced radiation sensitivity in vitro. These effects were tied to the depletion of GGPP and the decreased phosphorylation of ERK1/2, suggesting a prominent role for the EGFR-RAS-ERK1/2 pathway, through which statin enhances radiation sensitivity.