Assessment of Biomarker Heterogeneity in Sinus Versus Inferior Turbinate Tissue in Patients Without Chronic Rhinosinusitis.

Taylor R CarleTara J WuVivian WungJeffrey D SuhMarilene B WangChristine R WellsMaura RossettiJivianne T Lee

Published in: American journal of rhinology & allergy (2021)

No consensus exists regarding the optimal choice of control specimen for CRS research. We present statistically significant quantitative differences in biomarker levels between paired inferior turbinate and sphenoid mucosa samples. This confirms the presence of heterogeneity between different subsites of sinonasal mucosa and highlights the need for standardization in future CRS research.

Keyphrases

chronic rhinosinusitis
end stage renal disease
single cell
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
high resolution
current status
patient reported outcomes