Development and validation of a gene model predicting lymph node metastasis and prognosis of oral squamous cell carcinoma based on single-cell and bulk RNA-seq analysis.
Pei-Zhen HanLi-Cheng TanQing-Si OuyangPeng-Cheng YuXiao ShiJia-Qian HuWen-Jun WeiZhong-Wu LuYu WangQing-Hai JiNing QuHua-Ming MaiYu-Long WangPublished in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2022)
In view of intratumoral heterogeneity, we found 60 genes associated with lymph node metastasis of oral squamous cell carcinoma. Subsequently, we constructed a five-gene signature that could improve the prediction of lymph node metastasis, clinical outcome, and promote individualized treatment strategies for oral squamous cell carcinoma.