Entinostat enhances the efficacy of chemotherapy in small cell lung cancer through S-phase arrest and decreased base excision repair.

Anna Solta Kristiina Boettiger Ildikó Kovács Christian Lang Zsolt Megyesfalvi Franziska Ferk Miroslav Mišík Konrad Hötzenecker Clemens Aigner Christian R Kowol Siegfried Knasmueller Michael Grusch Beáta Szeitz Melinda Rezeli Balázs Dome Karin Schelch

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

In this study, we decipher the molecular processes behind synergistic interactions between chemotherapy and HDAC inhibition. Moreover, we report novel mechanisms to overcome drug resistance in SCLC, which may be relevant to increase the therapeutic success.

Keyphrases

small cell lung cancer
locally advanced
cancer therapy
cell proliferation
histone deacetylase