Association of Clinically Evident Eye Movement Abnormalities With Motor and Cognitive Features in Patients With Motor Neuron Disorders.
Barbara PolettiFederica SolcaLaura CarelliAlberto DienaEleonora ColomboSilvia TorreAlessio MaranzanoLucia GrecoFederica CozzaAndrea LizioRoberta FerrucciFloriano GirottiFederico VerdeClaudia MorelliChristian LunettaVincenzo SilaniNicola TicozziPublished in: Neurology (2021)
Patients with ALS showed a range of clinically evident OMAs, and these alterations were significantly correlated with cognitive, but not behavioral, changes. OMAs may be a marker of neurodegeneration, and bedside assessment represents a rapid, highly specific tool for detecting cognitive impairment in ALS.