Cross-Tissue Single-Nucleus RNA Sequencing Discovers Tissue-Resident Adipocytes Involved in Propanoate Metabolism in the Human Heart.
Sankha Subhra DasAsha KarSandhya RajkumarSeung Hyuk T LeeMarcus AlvarezKirsi H PietiläinenPäivi PajukantaPublished in: Arteriosclerosis, thrombosis, and vascular biology (2023)
Overall, we introduce a new function and genetic link to coronary artery disease for the previously unexplored heart-resident adipocytes.
Keyphrases
- coronary artery disease
- adipose tissue
- patient safety
- heart failure
- endothelial cells
- quality improvement
- single cell
- atrial fibrillation
- percutaneous coronary intervention
- induced pluripotent stem cells
- genome wide
- cardiovascular events
- coronary artery bypass grafting
- high fat diet induced
- insulin resistance
- transcatheter aortic valve replacement