C5aR1 activation in mice controls inflammatory eosinophil recruitment and functions in allergic asthma.
Anna V WieseJannis DuhnRabia Ülkü KorkmazKatharina M QuellIbrahim OsmanFanny EnderTorsten SchröderIan P LewkowichSimon Patrick HoganMarkus Huber-LangFranziska GumprechtPeter KönigJörg KoehlYves LaumonnierPublished in: Allergy (2023)
We uncovered novel roles for C5aR1 in iEOS trafficking and activation, which affects key aspects of allergic inflammation such as AHR, ILC2 and T cell activation.