Identification of an Activating Mutation in the Extracellular Domain of HER2 Conferring Resistance to Pertuzumab.
Ying ZhangShanshan WuXinlei ZhuangGaoqi WengJiansheng FanXiaoyue YangYingchun XuLiqiang PanTingjun HouZhan ZhouRongchang ChenPublished in: OncoTargets and therapy (2019)
We demonstrated the loss-of-function mechanism underlying pertuzumab resistance in HER2-positive tumour cells bearing the S310F mutation.