Development of an Amine-Catalyzed Regioselective Synthesis of Pyrroles.
Taban K K KakaawlaJoseph P A HarrityPublished in: Organic letters (2017)
A regioselective synthesis of pyrroles has been devised through the cycloaddition of 1,3-oxazolium-5-olates and enamines. Product regiochemistry is controlled by the enamine substitution pattern. Moreover, an amine-catalyzed variant of this reaction allows aldehydes to be used directly as substrates for pyrrole synthesis.
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